Cancer Persister Cell
Adaptation - Gradualism - Optimality
mRNA N6-methyladenine modifications differentially regulate a sub-population of mRNAs translation in melanoma persister cells.
Persister metabolite
Rewired metabolism in persister cells renders these cells an altered metabolite profiles that can be secreted into the microenvironment and blood streams to modify the receiver cells.
Persister cells are slow-cyclying cells that do not depend on glucose, rather fatty acid oxidation provides an alternative way to support the survival.
Persister-immune interaction
Persister cells can sustain during years in patient bodies. The intriguing interaction between these cells and their immuno-microenvironment may be highlight a novel therapeutic opportunity.