An epitranscriptomic mechanism in melanoma persister cells
A subpopulation of BRAFV600 mutant melanoma persister cells that tolerates exposure to BRAF and MEK inhibitors undergoes a reversible remodelling of mRNA translation. Translation remodelling in persister cells coincides with an increased N6-methyladenosine modification in the 5′-untranslated region of some highly translated mRNAs. Combination of translation inhibitor with BRAF and MEK inhibitors effectively inhibits the emergence of persister cells