New article published!
A mathematical model to study the impact of intra-tumour heterogeneity on anti-tumour CD8+ T cell immune response.
New review published!
we discuss recent advances in understanding the relationship between mRNA translation and tumor-associated immunity, the potential mechanisms of immunotherapy resistance in cancers linked to translational reprogramming, and therapeutic perspectives and potential challenges of modulating translational regulation in cancer immunotherapy.
@ Cancer Research, AACR 2021
New article published! We have developped a proximity ligation assay-based detection of mRNA translation initiation complex eIF4F in situ and single-molecule image analysis tools for cellular translation activity monitoring.
@ Cell Press, STAR Protocols
Shensi Shen discusses mathematical oncology by modeling reversible state of persistent cancer cells @ SMB2021 symposium.
@ Univ. of California, Riverside, USA
One of the most famous french media: Le Monde Made a special issue for our work on persistent cancer cells (cellules persistantes). We need more attentions from the public to revive the cancer research.
@LeMonde,Paris,France
Persister cells are a small sub-population of cancer cells that maintain viability under anti-cancer treatments. These cells harbor non-genetic, reversible drug-resistance phenotypes. We are interested in understanding the underlying biological mechanisms.
Aberrant metabolism of cancer cells presents potential therapeutic opportunities. A growing interest focuses on how to target cancer metabolism. We are interested in metabolic rewiring in melanoma and lung cancers, paving the way to find new metabolic targets
Translating findings from single cell studies to clinical implementations of personalized medicine, paving the way to understand the heterogeneity of tumor intrinsic features, its microenvironment and tumor cell "quorum sensing" in the niche.
沈慎思
李开秀
蒲怡
卢天健
彭皓宁
王梦瑶
王之乐
Singapore-Sichuan Frontier Medical Center
West China hospital Chest Cancer Research Institute
D5-B building, Xin-chuan Road, Chengdu City, China 610200
shensi.sean@gmail.com
FOLLOW US!